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Ctc cancer trials breast

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A circulating tumor cell CTC is a cell that has shed into the vasculature or lymphatics [1] from a primary tumor and is carried around the body in the blood circulation. CTCs can extravasate and become seeds for the subsequent growth of additional tumors metastases in distant organs, a mechanism that is responsible for the vast majority of cancer-related deaths. The detection of CTCs, or liquid biopsy , presents several advantages over traditional tissue biopsies. They are non-invasive, can be used repeatedly, and provide more useful information on metastatic risk, disease progression, and treatment effectiveness. By contrast, analysis of solid tumors necessitates invasive procedures that might limit patient compliance.
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Circulating Tumor Cells in Breast Cancer

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Is One Biomarker Good Enough for Guiding Breast Cancer Tx? | MedPage Today

A prespecified circulating tumor cell count CTC threshold appeared to be reliable for selecting treatment with chemotherapy instead of hormone therapy in women with a certain metastatic breast cancer phenotype, a non-inferiority trial indicated. Median progression-free survival PFS was The threshold for non-inferiority was met, but not for superiority, the authors noted. They concluded that use of CTC count as a single biomarker was "a reliable, standardized option to guide the treatment choice between single-agent endocrine therapy and chemotherapy in hormone receptor-positive, ERBB2-negative MBC. In addition, more than one-third of patients had discordant CTC and clinical assessments. Overall survival in the per-protocol population was
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Is One Biomarker Good Enough for Guiding Breast Cancer Tx?

Metrics details. The primary endpoint was the overall response rate. Among 11 patients treated with T-DM1, one achieved a confirmed partial response. Four patients had a stable disease as best response.
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This is a promising time in metastatic breast cancer research. Many new treatments for metastatic breast cancer are under study and treatment is improving. Findings from clinical trials will determine whether or not these new treatments will become a part of standard care for metastatic breast cancer. Learn about clinical trials for people with metastatic breast cancer and access a web-based personalized clinical trial matching tool — the Metastatic Trial Search. They are used in combination with hormone therapy to treat hormone receptor-positive, HER2-negative metastatic breast cancers.
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